Respiratory infections
Molecular solutions for the currently evidenced scope
The current SYNTOL portfolio in this area is focused on SARS-CoV-2 RNA detection and combined detection of SARS-CoV-2, Influenza A and Influenza B. The laboratory sequence can include specimen handling, RNA extraction, RT-qPCR, a separate RT-LAMP approach, and supplementary S-gene sequencing.
This page helps laboratories choose a method and product for a defined task without implying universal coverage of respiratory infections. The currently evidenced scope is SARS-CoV-2 and SARS-CoV-2 + Influenza A/B.
Laboratory tasks
- transport and store clinical material covered by the assay;
- extract RNA manually or using documented automation;
- detect SARS-CoV-2 RNA by RT-qPCR;
- perform combined detection of SARS-CoV-2 and Influenza A/B;
- use RT-LAMP for SARS-CoV-2 where supported by the assay;
- perform amplification and Sanger sequencing of the S gene for the relevant specialized task.
Analytical sequence
Specimen handling
A transport medium can support relevant clinical-material applications.
RNA extraction
M-Sorb-NA supports magnetic RNA extraction in manual and documented automated configurations.
Primary detection
The SARS-CoV-2 RT-PCR family addresses SARS-CoV-2 detection, while CoV-2-FluA/B-RT-PCR addresses the combined SARS-CoV-2 + Influenza A/B task.
Alternative method
KoviGen-LAMP-01 provides a separate RT-LAMP approach to SARS-CoV-2 RNA detection.
Supplementary analysis
AmpliSeng S-gene SARS-CoV-2 supports S-gene amplification and sequencing and is not a replacement for the primary detection stage.
RT-qPCR is the principal method on this page. RT-LAMP is a separate isothermal approach for a specific product, while Sanger sequencing is an additional method for the separate S-gene analysis task.
Products for key stages
The three principal tasks are SARS-CoV-2 detection by RT-qPCR, combined SARS-CoV-2 and Influenza A/B detection, and a dedicated RT-LAMP approach. RNA extraction, transport medium, and Sanger sequencing support these analytical routes.
Transport medium. Reagent for transport and storage clinical material, including SARS-CoV-2, (form 1 – 100 tubes by 0,7 mL, form 2 – 1 l)
Reagent kit "RT-1"for performing reverse transcription
"AmpliSeng-S-gene-SARS-CoV-2" reagent kit for amplification and sequencing of the SARS-CoV-2 S gene
"M-Sorb-Nucleic Acids" reagent kit for manual RNA isolation and use on automated magnetic-separation stations
"CoviGen-LAMP-01" reagent kit for detection of SARS-CoV-2 RNA by real-time reverse-transcription loop-mediated isothermal amplification
Reagent kit "real-time RT-PCR-SARS-CoV-2"for detection of RNA coronavirus SARS-CoV-2 by real-time polymerase chain reaction, configuration: presentation 3
Reagent kit "real-time RT-PCR-SARS-CoV-2"for detection of RNA coronavirus SARS-CoV-2 by real-time polymerase chain reaction, configuration: presentation 1
Reagent kit "real-time RT-PCR-SARS-CoV-2"for detection of RNA coronavirus SARS-CoV-2 by real-time polymerase chain reaction, configuration: presentation 2
Reagent kit "real-time RT-PCR-SARS-CoV-2"for detection of RNA coronavirus SARS-CoV-2 by real-time polymerase chain reaction, configuration: presentation 2
Reagent kit "real-time RT-PCR-SARS-CoV-2"for detection of RNA coronavirus SARS-CoV-2 by real-time polymerase chain reaction, configuration: presentation 2
Reagent kit «CoV-2-FluA/B-RT-PCR» for detection of RNA coronavirus SARS-CoV-2, viruses influenza A (Influenza A virus) and influenza B (Influenza B virus) by real-time PCR…
Reagent kit «CoV-2-FluA/B-RT-PCR» for detection of RNA coronavirus SARS-CoV-2, viruses influenza A (Influenza A virus) and influenza B (Influenza B virus) by real-time PCR…
Move from the task to concrete resources
Combinations of PCR and Isothermal Amplification Techniques Are Suitable for Fast and Sensitive Detection of SARS-CoV-2 Viral RNA
Open material↗User Training
Practical user training for working with reagents, protocols and laboratory scenarios.
Open service↗Scope and limitations
This section is limited to evidenced SARS-CoV-2 and SARS-CoV-2 + Influenza A/B tasks. Sensitivity, specificity, turnaround, registration status, and equipment compatibility belong to the specific assay. The section is not intended for treatment, prognosis, or patient-management conclusions.
Select a solution
Primary action: “Select a test by analytical task.” Choose SARS-CoV-2, SARS-CoV-2 + Influenza A/B, RT-LAMP, RNA extraction, or supplementary sequencing. Additional actions: “Check compatibility” and “Request training.”
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